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Django is a high-level Python web framework that encourages rapid development and clean, pragmatic design. It follows the model-view-controller (MVC) architectural pattern, providing an extensive set of built-in tools and conventions to streamline the creation of robust and scalable web applications.

Flask is a lightweight and popular web framework for Python, known for its simplicity and flexibility. It is widely used to build web applications, providing a minimalistic approach to web development with features like routing, templates, and support for extensions.