Bootstrap is the most popular CSS Framework for developing responsive and mobile-first websites.
Bulma is a free, open source CSS framework based on Flexbox and built with Sass. It's 100% responsive, fully modular, and available for free.
Semantic UI is a popular front-end development framework that provides a set of pre-designed user interface components to help developers create responsive and mobile-friendly web applications with ease. It emphasizes a clear and intuitive naming convention for CSS classes, making it easier to customize and maintain the design of web applications.